DIS3L
Description
The DIS3L (DIS3 like exosome 3'-5' exoribonuclease) is a protein-coding gene located on chromosome 15.
DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.
DIS3L is a catalytic component of the RNA exosome complex, exhibiting 3'-to-5' exoribonuclease activity. It participates in numerous cellular RNA processing and degradation events, including general mRNA turnover, specifically degrading unstable mRNAs with AU-rich elements in their 3' untranslated regions. It also plays a role in RNA surveillance pathways, preventing the translation of aberrant mRNAs. Additionally, DIS3L appears to be involved in the degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389, ECO:0000269|PubMed:37602378}
DIS3L is also known as DIS3L1.
