DIDO1
Description
The DIDO1 (death inducer-obliterator 1) is a protein-coding gene located on chromosome 20.
DIDO1, a protein encoded by the DIDO1 gene in humans, plays a significant role in apoptosis, a crucial process for eliminating unwanted cells during development and maintaining homeostasis in multicellular organisms. In mice, DIDO1 is activated by apoptotic signals and translocates from the cytoplasm to the nucleus. When overexpressed, it triggers apoptosis in cell lines. This gene is similar to its mouse counterpart, suggesting its involvement in apoptosis in humans. Alternative splicing of the DIDO1 gene results in multiple protein isoforms.
DIDO1 is a putative transcription factor that promotes apoptosis when overexpressed. It acts as a tumor suppressor and plays a crucial role in early embryonic stem cell development. DIDO1 is necessary for the differentiation of embryonic stem cells by displacing isoform 4 and repressing stemness genes.
DIDO1 is also known as BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8.
