DHX34
Description
The DHX34 (DExH-box helicase 34) is a protein-coding gene located on chromosome 19.
DHX34 is a protein encoded by the DHX34 gene in humans. It belongs to the DEAD box protein family, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), which is associated with RNA helicase activity. DHX34 is involved in various cellular processes that involve alterations in RNA secondary structure, including translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. It's believed to play a role in embryogenesis, spermatogenesis, and cellular growth and division. DHX34 is located in the glioma 19q tumor suppressor region, making it a potential tumor suppressor gene.
DHX34 is a probable ATP-binding RNA helicase that plays a crucial role in nonsense-mediated decay (NMD) of mRNA transcripts with premature stop codons. It promotes the phosphorylation of UPF1, enhancing its interaction with essential NMD pathway proteins like UPF2 and EIF4A3. DHX34 interacts with the RUVBL1-RUVBL2 complex, leading to a reduction in its nucleotide binding ability and ATP hydrolysis. DHX34 negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex by inducing conformational changes in the RUVBL2 subunits.
DHX34 is also known as DDX34, HRH1.
