DHX16
Description
The DHX16 (DEAH-box helicase 16) is a protein-coding gene located on chromosome 6.
DHX16 is an enzyme encoded by the DHX16 gene in humans. It belongs to the DEAD box protein family, which are RNA helicases involved in various cellular processes like translation initiation, splicing, and ribosome assembly. DHX16 is a functional homolog of the fission yeast Prp8 protein, which is involved in cell cycle progression. The DHX16 gene is located on chromosome 6p21.3, within the MHC region known for its association with various diseases.
DHX16 is required for pre-mRNA splicing as a component of the spliceosome. It contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. DHX16 is also a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. DHX16 plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.
DHX16 is also known as DBP2, DDX16, NMOAS, PRO2014, PRP8, PRPF2, Prp2.
