DGKA
Description
The DGKA (diacylglycerol kinase alpha) is a protein-coding gene located on chromosome 12.
Diacylglycerol kinase alpha is an enzyme encoded by the DGKA gene in humans. It belongs to the eukaryotic diacylglycerol kinase family and acts as a modulator that competes with protein kinase C for diacylglycerol in intracellular signaling pathways. It is crucial for the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus, leading to four transcript variants encoding the same protein.
Diacylglycerol kinase that converts diacylglycerol (DAG) into phosphatidic acid (PA) and regulates their respective levels. This enzyme acts as a central switch between signaling pathways activated by these bioactive lipids with different cellular targets and opposite effects in various biological processes. It also plays a role in the biosynthesis of complex lipids and can phosphorylate 1-alkyl-2-acylglycerol containing an arachidonoyl group. Furthermore, it is involved in the production of alkyl-lysophosphatidic acid through the phosphorylation of 1-alkyl-2-acetyl glycerol. {ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712, ECO:0000269|PubMed:22627129, ECO:0000305}
DGKA is also known as DAGK, DAGK1, DGK-alpha.
Associated Diseases
- ovarian cancer
- cancer
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- lung cancer
- spermatogenic failure 3
- spermatogenic failure 26
- spermatogenic failure 31
- spermatogenic failure 23
- spermatogenic failure 52
