RNF113A
Description
The RNF113A (ring finger protein 113A) is a protein-coding gene located on chromosome X.
RNF113A, encoded by the RNF113A gene located on the X chromosome, is a protein containing two conserved domains: the RING finger domain and the Zinc finger domain. These domains play roles in protein-protein interactions, DNA repair, and are associated with tumor suppressors and cytokine receptor-associated molecules. RNF113A is an intronless gene with one isoform. It resides on the X chromosome's reverse strand at locus Xq24 and spans 1312 nucleotides.
RNF113A is a key component of the spliceosome, essential for pre-mRNA splicing. It participates in the minor spliceosome, specifically involved in splicing U12-type introns within pre-mRNAs. As an E3 ubiquitin-protein ligase, it catalyzes the transfer of ubiquitin to target proteins, including SNRNP200/BRR2, which it polyubiquitinates using non-canonical 'Lys-63'-linked polyubiquitin chains. This ligase activity plays a role in DNA repair by recruiting ALKBH3 and the ASCC complex to sites of DNA damage caused by alkylating agents. Additionally, RNF113A ubiquitinates CXCR4, leading to its degradation and termination of CXCR4 signaling.
RNF113A is also known as Cwc24, RNF113, TTD5, ZNF183.
