KRT74

Description

The KRT74 (keratin 74) is a protein-coding gene located on chromosome 12.

KRT74 is a gene responsible for producing a type of keratin protein. Mutations in this gene can lead to hair and nail ectodermal dysplasia, a condition affecting hair and nail development.

KRT74 plays a crucial role in hair formation by contributing to the structural integrity of the hair follicle's inner root sheath (IRS). It is believed to be a key component of keratin intermediate filaments within the IRS.

KRT74 is also known as ADWH, ECTD7, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4.

Associated Diseases

• Woolly hair
• Hypotrichosis simplex of the scalp
• Hypotrichosis 3
• Woolly hair, autosomal dominant
• Ectodermal dysplasia 7, Hair/nail type