WNT10B

Description

The WNT10B (Wnt family member 10B) is a protein-coding gene located on chromosome 12.

The WNT10B gene encodes for the Wnt-10b protein, also known as Wnt-12. It belongs to the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins involved in oncogenesis and various developmental processes, including cell fate and patterning during embryogenesis. This gene may play a role in breast cancer and its protein signaling is thought to be a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has been shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis. The WNT10B protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.

WNT10B is also known as SHFM6, STHAG8, WNT-12.

Associated Diseases

• Oligodontia
• Tooth agenesis, selective, 8
• Split-Hand/foot malformation 6
• Isolated split hand-split foot malformation