TSPEAR
Description
The TSPEAR (thrombospondin type laminin G domain and EAR repeats) is a protein-coding gene located on chromosome 21.
TSPEAR plays a critical role in tooth and hair follicle development by regulating the Notch signaling pathway. It may also be involved in the development or function of the auditory system.
TSPEAR is also known as C21orf29, DFNB98, ECTD14, STHAG10, TSP-EAR.
Associated Diseases
- Ectodermal dysplasia 14, hair/tooth type with or without hypohidrosis
- Tooth agenesis, selective, 10
- Deafness, autosomal recessive 98
