SULT2B1
Description
The SULT2B1 gene encodes the enzyme sulfotransferase 2B1, a crucial player in the detoxification and metabolism of steroid hormones. This enzyme primarily acts on dehydroepiandrosterone (DHEA) and its sulfate conjugate, DHEA-S. SULT2B1 plays a significant role in regulating the levels of these hormones, impacting various physiological processes, including growth, development, and reproduction. Its activity is influenced by factors like age, sex, and genetic variations, making it a fascinating target for research.
Associated Diseases
- Polycystic ovary syndrome (PCOS)
- Adrenal insufficiency
- Congenital adrenal hyperplasia
- Neurodevelopmental disorders
- Cancer
Did you know?
SULT2B1 activity exhibits a distinct sex difference, with higher levels observed in females compared to males. This difference might contribute to the observed sex disparities in steroid hormone metabolism.
