LZTR1 : leucine zipper like post translational regulator 1
Description
The LZTR1 (leucine zipper like post translational regulator 1) is a protein-coding gene located on chromosome 22.
The LZTR1 gene encodes a protein with an unknown precise function. It is present in cells throughout the body, primarily localized within the Golgi apparatus, where it likely helps stabilize this structure. Research suggests a possible role for the LZTR1 protein in the CUL3 ubiquitin ligase complex, involved in the degradation of unnecessary proteins. Due to its involvement in various tumor types, the LZTR1 protein is believed to act as a tumor suppressor, preventing uncontrolled cell growth and division.
LZTR1 acts as a substrate-specific adapter within the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, directly mediating the ubiquitination of Ras proteins (K-Ras/KRAS, N-Ras/NRAS, and H-Ras/HRAS). This process plays a crucial role in regulating RAS-MAPK signaling, with LZTR1 acting as a negative regulator. It achieves this by controlling Ras levels and reducing Ras association with cellular membranes.
LZTR1 is also known as BTBD29, LZTR-1, NS10, NS2, SWNTS2.
Associated Diseases
- Full schwannomatosis
- Schwannomatosis 2
- Noonan syndrome 2
- Noonan syndrome 10
- Noonan syndrome
- Schwannomatosis
