LAMB3 : laminin subunit beta 3
Description
The LAMB3 (laminin subunit beta 3) is a protein-coding gene located on chromosome 1.
The LAMB3 gene instructs the production of the beta subunit of laminin-332, a protein essential for skin health. Laminins are a group of proteins involved in cell growth, movement, and attachment. Laminin-332 is particularly important in the skin's basement membrane, providing strength and resilience. It also helps connect the two layers of the basement membrane, creating a barrier. Beyond skin, laminin-332 likely plays roles in wound healing, cornea development, and tooth enamel formation.
LAMB3 is also known as AI1A, BM600-125KDA, JEB1A, JEB1B, LAM5, LAMNB1.
Associated Diseases
- Severe generalized junctional epidermolysis bullosa
- Epidermolysis bullosa, junctional, Non-Herlitz type
- Epidermolysis bullosa, junctional, Herlitz type
- Amelogenesis imperfecta, type IA
- Intermediate generalized junctional epidermolysis bullosa
- Amelogenesis imperfecta
- Junctional epidermolysis bullosa
