KREMEN1
Description
The KREMEN1 (kringle containing transmembrane protein 1) is a protein-coding gene located on chromosome 22.
Kremen1 protein is encoded by the KREMEN1 gene in humans. This protein is highly conserved across various species, including vertebrates and amphioxus. Kremen1 acts as a type I transmembrane receptor, binding to ligands like Dickkopf proteins (DKK1-4), EpCAM, and Rspondin1. It functions as a high-affinity receptor for DKK1 and works together with DKK1 to inhibit Wnt/beta-catenin signaling. Kremen1 is part of a membrane complex that regulates canonical Wnt signaling through LRP6. It features extracellular Kringle, WSC, and CUB domains. Different isoforms of Kremen1 exist due to alternative splicing. Kremen1 also contributes to cell death through apoptosis. This pro-apoptotic activity is dependent on the absence of the ligand Dickkopf1. These characteristics have led to the classification of Kremen1 as a Dependence Receptor.
KREMEN1 is also known as ECTD13, KREMEN, KRM1.
