HOXC13

Description

The HOXC13 gene plays a crucial role in the development of limbs, particularly the distal regions such as hands and feet. It belongs to the HOX gene family, which encodes transcription factors that control the expression of other genes during embryonic development. HOXC13 is activated in the developing limb bud and guides the formation of the digits, bones, and other structures. Mutations in HOXC13 can lead to a range of limb malformations, highlighting its importance in normal limb development.

Associated Diseases

• Synpolydactyly
• Brachydactyly
• Hand-foot-genital syndrome
• Nail-patella syndrome
• Split-hand/split-foot malformation
• Ulnar-mammary syndrome

Did you know?

HOXC13 is also involved in the development of other tissues, such as the reproductive organs and the nervous system.