EOGT : EGF domain specific O-linked N-acetylglucosamine transferase
Description
The EOGT (EGF domain specific O-linked N-acetylglucosamine transferase) is a protein-coding gene located on chromosome 3.
The EOGT gene provides instructions for producing a protein that modifies other proteins by attaching a molecule called N-acetylglucosamine (GlcNAc). This process, known as O-GlcNAc modification, can affect protein stability and regulate various cellular processes, such as signaling within cells and the initial step of protein synthesis from genes (transcription). The specific proteins modified by the EOGT protein and the effects of O-GlcNAc modification on them are largely unknown. Research suggests that Notch proteins might be modified by EOGT. Notch proteins play a crucial role in signaling pathways that are essential for the development of various tissues throughout the body, including bones, heart, liver, muscles, and blood cells.
EOGT catalyzes the addition of a single N-acetylglucosamine (GlcNAc) molecule from UDP-GlcNAc to a serine or threonine residue in extracellular proteins. This modification, known as O-GlcNAc glycosylation, involves attaching GlcNAc to the protein via a beta-linkage. EOGT specifically targets the threonine residue found between the fifth and sixth conserved cysteine residues within folded EGF-like domains.
EOGT is also known as AER61, AOS4, C3orf64, EOGT1.
