ALOX12B : arachidonate 12-lipoxygenase, 12R type

Description

The ALOX12B gene, encodes 12/15-lipoxygenase, a crucial enzyme involved in the biosynthesis of various bioactive lipid mediators. These mediators, such as leukotrienes and lipoxins, play critical roles in inflammation, immunity, and lipid metabolism. ALOX12B‘s expression is particularly prominent in leukocytes, epithelial cells, and the gastrointestinal tract, highlighting its involvement in diverse biological processes.

Associated Diseases

• Asthma
• Chronic Obstructive Pulmonary Disease (COPD)
• Inflammatory Bowel Disease (IBD)
• Atherosclerosis
• Cancer

Did you know?

ALOX12B is involved in the production of lipoxins, which have anti-inflammatory properties and can actually counterbalance the pro-inflammatory effects of other lipid mediators, like leukotrienes.