DEPTOR
Description
The DEPTOR (DEP domain containing MTOR interacting protein) is a protein-coding gene located on chromosome 8.
DEPTOR (DEP domain-containing mTOR-interacting protein), also known as DEPDC6, is a protein encoded by the DEPTOR gene in humans. The gene is found only in vertebrates and is located on chromosome 8, specifically at 8q24.12. The protein consists of 409 amino acids and contains two N-terminal DEP domains and a C-terminal PDZ domain. DEPTOR plays a crucial role in the mTOR signaling pathway as an endogenous regulator. It directly interacts with mTOR, and its overexpression downregulates the activity of both mTORC1 and mTORC2 in vitro. These complexes can inhibit DEPTOR through phosphorylation. DEPTOR is involved in regulating adipogenesis and muscle fiber type switching. In muscle cells, it promotes a switch from oxidative to glycolytic myofiber type through Akt/PKB activation.
DEPTOR acts as a negative regulator of both mTORC1 and mTORC2 complexes. It inhibits the protein kinase activity of MTOR, leading to the inactivation of these complexes. This inhibition promotes autophagy by suppressing the activity of mTORC1 and mTORC2. However, DEPTOR only partially inhibits mTORC1 activity compared to AKT1S1/PRAS40.
DEPTOR is also known as DEP.6, DEPDC6, hDEPTOR.
