DENR
Description
The DENR (density regulated re-initiation and release factor) is a protein-coding gene located on chromosome 12.
DENR may refer to:
DENR, in conjunction with MCTS1, plays a crucial role in regulating the translation of target mRNAs by recognizing and binding to the initiation codon. It actively participates in the initiation of translation, facilitating the recruitment of aminoacylated initiator tRNA to the P site of 40S ribosomes. Additionally, DENR promotes the release of deacylated tRNA and mRNA from recycled 40S subunits, following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. This protein's function extends to modulating the translational profile of a specific set of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
DENR is also known as DRP, DRP1, SMAP-3.
Associated Diseases
- isolated asymptomatic elevation of creatine phosphokinase
- plasma fibronectin deficiency
- pentosuria
- myopathy due to calsequestrin and SERCA1 protein overload
- metabolic myopathy due to lactate transporter defect
- cancer
- Parkinson disease
- retinal degeneration
