DDX60
Description
The DDX60 (DExD/H-box helicase 60) is a protein-coding gene located on chromosome 4.
DDX60 plays a crucial role in the immune response to viral infections by positively regulating the production of type I interferon and interferon-inducible genes. It achieves this by interacting with key immune sensors like RIG-I and MDA5, which detect viral RNA. DDX60 binds to various nucleic acids, including single-stranded RNA (ssRNA), double-stranded RNA (dsRNA), and double-stranded DNA (dsDNA), and can enhance the binding of RIG-I to dsRNA. These interactions contribute to the activation of antiviral signaling pathways and the production of antiviral factors. DDX60 has been shown to exhibit antiviral activity against specific viruses such as hepatitis C virus and vesicular stomatitis virus (VSV).
DDX60 is also known as -.
