DDI2
Description
The DDI2 (DNA damage inducible 1 homolog 2) is a protein-coding gene located on chromosome 1.
DDI2 is an aspartic protease that cleaves NFE2L1/NRF1 at 'Leu-104', releasing it from the endoplasmic reticulum membrane. This cleavage requires ubiquitination of NFE2L1/NRF1, suggesting DDI2 specifically binds ubiquitinated NFE2L1/NRF1. DDI2 acts as a proteasomal shuttle, linking the proteasome to replication fork proteins like RTF2. It is required, with DDI1, for cell survival following replication stress. Together with DDI1, DDI2 removes RTF2 from stalled replication forks, enabling cell cycle progression and maintaining genome integrity.
DDI2 is also known as -.
