DCUN1D3
Description
The DCUN1D3 (defective in cullin neddylation 1 domain containing 3) is a protein-coding gene located on chromosome 16.
DCUN1D3 plays a role in the neddylation of cullins, a process where a small protein called NEDD8 is attached to cullins. This process is important for the proper functioning of cullins, which are involved in protein degradation. DCUN1D3 helps transfer NEDD8 from an enzyme called NEDD8-conjugating E2s to cullins. This activity is thought to be important for cell cycle progression and for regulating the activity of a protein complex called SCF ubiquitin E3 ligase, particularly after UV damage. DCUN1D3 can also promote or inhibit neddylation at the cell membrane. {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:27542266}
DCUN1D3 is also known as 44M2.4, DCNL3, SCCRO3.
Associated Diseases
- diabetes mellitus, permanent neonatal 4
- permanent neonatal diabetes mellitus 1
- dehydrated hereditary stomatocytosis
- sideroblastic anemia 3
- congenital dyserythropoietic anemia type 4
- glycogen storage disease VI
- hyperinsulinism due to INSR deficiency
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- megaloblastic anemia, folate-responsive
- coronary artery disease, autosomal dominant 2
- familial partial lipodystrophy, Dunnigan type
- Rh deficiency syndrome
