DCUN1D2
Description
The DCUN1D2 (defective in cullin neddylation 1 domain containing 2) is a protein-coding gene located on chromosome 13.
DCUN1D2 facilitates the attachment of NEDD8 (a small protein) to all cullins. This process, called neddylation, involves transferring NEDD8 from specific E2 enzymes (UBE2M and UBE2F) to cullin complexes. Neddylation is essential for the proper function of SCF (SKP1-CUL1-F-box protein) complexes, which are involved in protein degradation.
DCUN1D2 is also known as C13orf17, DCNL2.
Associated Diseases
- epidermolysis bullosa simplex with nail dystrophy
- nonpapillary renal cell carcinoma
- hereditary peripheral neuropathy
