DCUN1D1
Description
The DCUN1D1 (defective in cullin neddylation 1 domain containing 1) is a protein-coding gene located on chromosome 3.
DCUN1D1 is a protein encoded by the DCUN1D1 gene in humans. It is amplified in several types of cancer, including squamous cell cancers, and may act as an oncogenic driver in cancer cells. DCUN1D1 interacts with CAND1, CUL1, CUL2, CUL3, and RBX1.
DCUN1D1 is a component of an E3 ubiquitin ligase complex responsible for neddylation. It promotes neddylation of cullin components within these complexes, which are crucial for protein degradation. DCUN1D1 facilitates this process by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation. It enhances the recruitment of E2-NEDD8 thioester to the complex, optimizing protein orientation to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Notably, DCUN1D1 plays a role in releasing the inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. Additionally, DCUN1D1 acts as an oncogene, promoting malignant transformation and cancerous progression.
DCUN1D1 is also known as DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3.
Associated Diseases
- Parkinson disease
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- alopecia
- spermatogenic failure 65
- spermatogenic failure 51
- spermatogenic failure 39
- spermatogenic failure, X-linked, 3
- spermatogenic failure 42
- spermatogenic failure 72
- spermatogenic failure 40
- spinocerebellar ataxia type 32
