DAAM1
Description
The DAAM1 (dishevelled associated activator of morphogenesis 1) is a protein-coding gene located on chromosome 14.
DAAM1 (Dishevelled-associated activator of morphogenesis 1) is a protein encoded by the DAAM1 gene in humans. It plays a crucial role in cell motility, adhesion, and cytokinesis by regulating the actin cytoskeleton. DAAM1 contains formin homology (FH) domains and belongs to a novel subfamily of FH proteins involved in cell polarity. It is involved in Wnt/Fz signaling, where it activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. DAAM1 facilitates the formation of a Dvl-Rho complex, acting as a scaffolding protein. A deletion of a single copy of the DAAM1 gene has been linked to congenital heart defects.
DAAM1 interacts with Dishevelled (Dvl) and Rho, facilitating the formation of a Wnt-induced Dvl-Rho complex. It potentially acts as a scaffolding protein, recruiting Rho-GDP and Rho-GEF, thereby promoting Rho-GTP production. DAAM1 can initiate the formation and elongation of new actin filaments. It is implicated in the development of functional cilia (PubMed:16630611, PubMed:17482208) and the organization of the subapical actin network in multiciliated epithelial cells (By similarity). In conjunction with DAAM2, DAAM1 is essential for myocardial maturation and sarcomere assembly (By similarity).
DAAM1 is also known as -.
Associated Diseases
- endometrial cancer
- isolated asymptomatic elevation of creatine phosphokinase
- plasma fibronectin deficiency
- pentosuria
- idiopathic pulmonary arterial hypertension
