CYP4Z1
Description
The CYP4Z1 (cytochrome P450 family 4 subfamily Z member 1) is a protein-coding gene located on chromosome 1.
CYP4Z1 (cytochrome P450, family 4, subfamily Z, polypeptide 1) is a protein encoded by the CYP4Z1 gene in humans. It belongs to the cytochrome P450 superfamily of enzymes, which are monooxygenases involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. The CYP4Z1 gene is located on chromosome 1p33. Elevated levels of CYP4Z1 have been observed in breast cancer cells, where its overexpression is linked to increased production of 20-Hydroxyeicosatetraenoic acid (20-HETE), a molecule suspected to contribute to breast cancer cell growth and spread. Similar overexpression has also been noted in ovarian cancer cells. These findings suggest that CYP4Z1 may serve as a valuable marker for distinguishing between benign and malignant breast and ovarian tumors, and for predicting the course of these malignancies.
CYP4Z1 is an enzyme that catalyzes the oxidation of fatty acids, specifically by adding an oxygen atom to the carbon-hydrogen bonds within the fatty acid chain. It primarily hydroxylates lauric and myristic acids at their omega-4 and omega-2 positions, respectively. CYP4Z1 also participates in the epoxidation of double bonds in polyunsaturated fatty acids (PUFAs), demonstrating a high degree of specificity in the epoxidation of arachidonic acid, producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer. This process involves the use of molecular oxygen, where one oxygen atom is incorporated into the substrate, and the other is reduced to water, with electrons supplied by NADPH through cytochrome P450 reductase.
CYP4Z1 is also known as CYP4A20.
