CYP4X1
Description
The CYP4X1 (cytochrome P450 family 4 subfamily X member 1) is a protein-coding gene located on chromosome 1.
CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein encoded by the CYP4X1 gene in humans. It belongs to the cytochrome P450 superfamily of enzymes, which are monooxygenases involved in many reactions like drug metabolism and synthesis of cholesterol, steroids, and other lipids. The expression pattern of a similar protein in rats suggests that CYP4X1 might be involved in neurovascular function in the brain.
CYP4X1 is a cytochrome P450 monooxygenase that specifically catalyzes the epoxidation of the last double bond in the arachidonoyl part of anandamide. This process potentially regulates endocannabinoid signaling. Notably, CYP4X1 lacks hydroxylase activity towards various fatty acids, steroids, and prostaglandins. The enzyme utilizes molecular oxygen, incorporating one oxygen atom into a substrate and reducing the second into water. This reaction is driven by two electrons supplied by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
CYP4X1 is also known as CYPIVX1.
