CYP4F3

Description

The CYP4F3 (cytochrome P450 family 4 subfamily F member 3) is a protein-coding gene located on chromosome 19.

Cytochrome P450 4F3, also leukotriene-B(4) omega-hydroxylase 2, is an enzyme that in humans is encoded by the CYP4F3 gene. CYP4F3 encodes two distinct enzymes, CYP4F3A and CYP4F3B, which originate from the alternative splicing of a single pre-mRNA precursor molecule; selection of either isoform is tissue-specific with CYP3F3A being expressed mostly in leukocytes and CYP4F3B mostly in the liver.

== Function == The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, fatty acids and other lipids. CYP4F3 actually encodes two splice-variants, CYP4F3A and CYP4F3B, of the cytochrome P450 superfamily of enzymes. The gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Both variants localize on the endoplasmic reticulum and metabolize leukotriene B4 and very likely 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and 12-hydroxyeicosatetraenoic acid by an omega oxidation reaction, i.e. by adding a hydroxyl residue to their terminal (i.e. C-20) carbon. This addition starts the process of inactivating and degrading all of these well-known mediators of inflammation CYP3FA is the major enzyme accomplishing these omega oxidations in leukocytes.

CYP4F3 is a cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). It uses molecular oxygen to insert one oxygen atom into a substrate, reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). CYP4F3 may play a role in inactivation of pro-inflammatory and anti-inflammatory oxylipins during the resolution of inflammation.

CYP4F3 is also known as CPF3, CYP4F, CYPIVF3, LTB4H.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing