CYP4F11

Description

The CYP4F11 (cytochrome P450 family 4 subfamily F member 11) is a protein-coding gene located on chromosome 19.

CYP4F11 (cytochrome P450, family 4, subfamily F, polypeptide 11) is a protein encoded by the CYP4F11 gene in humans. It belongs to the cytochrome P450 superfamily of enzymes, which are monooxygenases involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The CYP4F11 gene is located on chromosome 19, within a cluster of cytochrome P450 genes. Another member of this family, CYP4F2, is approximately 16 kb away. CYP4F11 is expressed in various tissues, including liver, kidney, heart, brain, and skeletal muscle. It is also overexpressed in ovarian and colon cancers. Notably, its gene has an estrogen receptor α responsive site in its promoter, potentially relevant to its overexpression in ovarian cancer. CYP4F11 participates in the metabolism of numerous drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine, and erythromycin. It can also hydroxylate short-chain and 3-hydroxylated medium chain fatty acids through omega oxidation, a reaction essential for processing these fatty acids. Additionally, CYP4F11 omega-hydroxylates Vitamin Ks, including menaquinone, in a metabolic step crucial for their further metabolism by beta oxidation and subsequent removal by catabolism, regulating their tissue levels.

CYP4F11 is a cytochrome P450 monooxygenase that plays a role in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). It uses molecular oxygen to insert one oxygen atom into a substrate and reduce the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase. CYP4F11 efficiently catalyzes the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids. It also omega-hydroxylates and inactivates phylloquinone (vitamin K1) and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. CYP4F11 metabolizes fatty acids with lower efficiency, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE). It catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine, and verapamil. Additionally, it catalyzes the oxidation of dialkylresorcinol 2.

CYP4F11 is also known as CYPIVF11.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing