CYP4A22
Description
The CYP4A22 (cytochrome P450 family 4 subfamily A member 22) is a protein-coding gene located on chromosome 1.
CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22), also known as fatty acid omega-hydroxylase, is a protein encoded by the CYP4A22 gene in humans. It belongs to the cytochrome P450 superfamily of enzymes, which are monooxygenases involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The CYP4A22 gene is located on chromosome 1p33, part of a cluster of cytochrome P450 genes. Although CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, to be involved in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) via omega oxidation, further research indicates that human CYP4A22 is expressed at very low levels in few tissues and may not be a functional enzyme in this regard. The primary enzymes responsible for 20-HETE synthesis in humans are CYP4F2, followed by CYP4A11. 20-HETE plays a role in regulating blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and potentially humans.
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.
CYP4A22 is also known as -.
Associated Diseases
- endometrial cancer
- urinary bladder cancer
- familial idiopathic steroid-resistant nephrotic syndrome
- glomerulopathy with fibronectin deposits 2
- nail-patella-like renal disease
- autosomal dominant progressive nephropathy with hypertension
- focal segmental glomerulosclerosis 5
- Liddle syndrome
- Denys-Drash syndrome
- primary membranoproliferative glomerulonephritis
- adenine phosphoribosyltransferase deficiency
- fibronectin glomerulopathy
- atypical hemolytic-uremic syndrome with C3 anomaly
- atypical hemolytic-uremic syndrome with B factor anomaly
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly
