CXXC5
Title: CXXC5: A Multifaceted Protein with Diverse Roles in Health and Disease
Description:
CXXC5 is a multifunctional protein involved in various cellular processes, including DNA repair, gene transcription, and cell cycle regulation. It contains a conserved CXXC motif that allows it to bind to unmethylated CpG dinucleotides, regulatory regions within the genome.
Associated Diseases:
Dysregulation of CXXC5 has been linked to several human diseases, including:
- Cancer: Aberrant CXXC5 expression has been observed in various cancer types, including breast, prostate, and colorectal cancer. It promotes tumorigenesis by regulating gene expression, cell proliferation, and DNA repair.
- Neurological Disorders: CXXC5 deficiency is associated with microcephaly, a condition characterized by a small head size and intellectual disability. It plays a crucial role in neuronal development and differentiation.
- Cardiovascular Disease: Reduced CXXC5 expression has been linked to increased susceptibility to heart failure and atherosclerosis. It regulates genes involved in cardiac function and protects against DNA damage.
Did you Know ?
- CXXC5 is one of the most commonly mutated genes in breast cancer, occurring in approximately 10-15% of cases.
