CXCL14
Description
The CXCL14 (C-X-C motif chemokine ligand 14) is a protein-coding gene located on chromosome 5.
CXCL14 is a small cytokine belonging to the CXC chemokine family, also known as BRAK (for breast and kidney-expressed chemokine). It shares many conserved features of the CXC chemokine subfamily but also has some differences, such as a shorter N-terminus and five extra amino acids between its third and fourth cysteines. CXCL14 is constitutively expressed at high levels in many normal tissues, with fibroblasts being its primary cellular source. However, its expression is reduced or absent in most cancer cells. CXCL14 is chemotactic for monocytes and can activate them in the presence of prostaglandin-E2 (PGE2). It is also a potent chemoattractant and activator of dendritic cells, involved in their homing, and can stimulate the migration of activated NK cells. CXCL14 inhibits angiogenesis, potentially through its ability to block endothelial cell chemotaxis. The CXCL14 gene consists of four exons and is located on chromosome 5 in humans.
CXCL14 is also known as BMAC, BRAK, KEC, KS1, MIP-2g, MIP2G, NJAC, SCYB14.
Associated Diseases
- glioblastoma
- lip and oral cavity carcinoma
- cancer
- lung cancer
- pachyonychia congenita
- plasma fibronectin deficiency
- isolated asymptomatic elevation of creatine phosphokinase
- congenital enteropathy due to enteropeptidase deficiency
