CTSL
Description
The CTSL (cathepsin L) is a protein-coding gene located on chromosome 9.
Cathepsin L can refer to:
Cathepsin L (CTSL) is a thiol protease that plays a critical role in various cellular processes, including protein turnover, antigen processing, and bone remodeling. It is involved in the degradation of proteins in lysosomes and participates in the solubilization of cross-linked thyroglobulin, leading to the release of thyroid hormone thyroxine. In neuroendocrine chromaffin cells, CTSL processes proenkephalin into the active enkephalin peptide neurotransmitter. Within the thymus, CTSL regulates CD4(+) T cell positive selection by generating MHCII-bound peptide ligands. It also mediates invariant chain processing in cortical thymic epithelial cells. As a major elastin-degrading enzyme at neutral pH, CTSL accumulates in the extracellular space of antigen-presenting cells during inflammation, contributing to extracellular matrix degradation. Its secreted form generates endostatin from COL18A1. CTSL is essential for cardiac morphology and function, hair follicle morphogenesis and cycling, and epidermal differentiation. It also promotes steroidogenesis stimulated by TIMP1.
CTSL is also known as CATL, CTSL1, MEP.
Associated Diseases
- COVID-19
- Parkinson disease
- lysosomal storage disease
- multiple sclerosis
- Alzheimer disease
- cancer
- hypotrichosis simplex
- alopecia, androgenetic, 1
- alopecia universalis congenita
- breast cancer
- Graham Little-Piccardi-Lassueur syndrome
