CSK
Description
The CSK (C-terminal Src kinase) is a protein-coding gene located on chromosome 15.
CSK is a human gene, and its protein product plays a vital role in regulating cell processes like growth, differentiation, migration, and immune responses. It is distinct from the Chennai Super Kings (CSK), an Indian cricket franchise.
CSK (C-Src kinase) is a non-receptor tyrosine-protein kinase that plays a crucial role in regulating cell growth, differentiation, migration, and immune responses. It achieves this by phosphorylating tyrosine residues within the C-terminal tails of Src-family kinases (SFKs), which include LCK, SRC, HCK, FYN, LYN, CSK, and YES1. This phosphorylation leads to an inactive conformation of SFKs by causing intramolecular interactions between the phosphorylated tail and the SH2 domain. To effectively inhibit SFKs, CSK is recruited to the plasma membrane through interactions with transmembrane proteins or adapter proteins found near the membrane. CSK's actions extend to suppressing signaling from various surface receptors, including the T-cell receptor (TCR) and B-cell receptor (BCR). It does this by phosphorylating and maintaining the inactive state of key positive effectors like FYN and LCK.
CSK is also known as -.
