CROCC


Description

The CROCC (ciliary rootlet coiled-coil, rootletin) is a protein-coding gene located on chromosome 1.

CROCC, also known as Rootletin, is a protein encoded by the CROCC gene in humans. It's a key component of the ciliary rootlet, a structure that extends from the basal body of a cilium towards the nucleus. Along with CEP68 and CEP250, CROCC is crucial for centrosome cohesion. CROCC's role in the ciliary rootlet is essential for its structure and function, making it a vital protein for mitosis. CROCC forms fibrous protein structures and contributes to the ciliary rootlet's structure. It also plays a role in centrosome cohesion before mitosis. CROCC interacts with C-Nap1, a large coiled-coil protein, through its fibrous tether, connecting to the proximal ends of centrioles.

CROCC is a major structural component of the ciliary rootlet, a cytoskeletal-like structure found in ciliated cells. The ciliary rootlet originates from the basal body at the proximal end of a cilium and extends towards the cell nucleus. CROCC is essential for proper positioning of the ciliary basal body relative to the nucleus, which is crucial for ciliogenesis. CROCC also contributes to centrosome cohesion before mitosis.

CROCC is also known as CROCC1, ROLT, TAX1BP2.

Associated Diseases



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