CRIM1
Description
The CRIM1 (cysteine rich transmembrane BMP regulator 1) is a protein-coding gene located on chromosome 2.
CRIM1 protein is encoded by the CRIM1 gene in humans. Motor neurons, among the earliest neurons to appear, differentiate in a ventral-to-dorsal gradient influenced by the concentration of sonic hedgehog protein (SHH). Dorsally expressed factors, like BMP4 and TGFB1, repress motor neuron induction. CRIM1 might interact with growth factors involved in motor neuron differentiation and survival. Loss of CRIM1 function in Crim1 KST264 hypomorph mice results in chronic kidney disease characterized by papillary hypoplasia, urinary tract obstruction, ectopic collagen accumulation, and tubulointerstitial fibrosis, potentially due to epithelial-mesenchymal transition.
CRIM1 is also known as CRIM-1, S52.
