CRACR2A
Description
The CRACR2A (calcium release activated channel regulator 2A) is a protein-coding gene located on chromosome 12.
Calcium release activated channel regulator 2A is a protein that in humans is encoded by the CRACR2A gene.
CRACR2A isoform 1 acts as a cytoplasmic calcium sensor, regulating CRAC channel activation in T-cells by promoting ORAI1 and STIM1 clustering at the junction of the plasma membrane and endoplasmic reticulum when calcium levels are low. This process involves translocation and clustering of ORAI1 and STIM1, ultimately leading to CRAC channel activation. As cytoplasmic calcium increases due to the opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, destabilizing the ORAI1-STIM1 complex.
CRACR2A is also known as EFCAB4B, RAB46.
