CR1

Description

The CR1 (complement C3b/C4b receptor 1 (Knops blood group)) is a protein-coding gene located on chromosome 1.

CR1 or CR-1 may refer to: Complement receptor type 1, also known as C3b/C4b receptor. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). (Microbial infection) Acts as a receptor for Epstein-Barr virus. Interacts (via Sushi 1 and Sushi 2 domains) with complement factor C4b (PubMed:2972794, PubMed:8175757). Interacts (via Sushi 8 and Sushi 9 domains) with complement factor C3b (PubMed:2972794, PubMed:8175757). Interacts (via Sushi 24 and Sushi 25 domains) with MBL2 (PubMed:23460739, PubMed:29563915). Interacts with FCN2 (PubMed:2972794). Interacts (via Sushi 24 and Sushi 25 domains) with C1QA (PubMed:29563915, PubMed:9324355). Interacts with CR2 (PubMed:1708808). (Microbial infection) Interacts with Epstein-Barr virus gp350.

CR1, also known as complement receptor type 1 or C3b/C4b receptor, is a membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. It mediates the binding of particles and immune complexes that have activated complement to these cells, eliminating them from the circulation. CR1 also inhibits spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases. It serves as a cofactor for the cleavage of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d by factor I. Additionally, CR1 contributes to immune regulation by promoting the generation of regulatory T cells from activated helper T cells upon ligand binding.

CR1 is also known as C3BR, C4BR, CD35, KN.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing