COX8C
Description
The COX8C (cytochrome c oxidase subunit 8C) is a protein-coding gene located on chromosome 14.
COX8C is a subunit of cytochrome c oxidase (complex IV), the final enzyme in the mitochondrial electron transport chain. This chain is comprised of several multi-subunit complexes that work together to transfer electrons from NADH and succinate to molecular oxygen. This process generates an electrochemical gradient across the inner mitochondrial membrane, which drives ATP synthesis. Cytochrome c oxidase catalyzes the reduction of oxygen to water. Electrons from reduced cytochrome c in the intermembrane space (IMS) are passed through the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). This BNC uses 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix to reduce molecular oxygen into 2 water molecules.
COX8C is also known as COX8-3.
