COX7A2
Description
The COX7A2 (cytochrome c oxidase subunit 7A2) is a protein-coding gene located on chromosome 6.
COX7A2 (Cytochrome c oxidase polypeptide 7A2, mitochondrial) is an enzyme encoded by the COX7A2 gene. It is a subunit of cytochrome c oxidase (COX), the final complex in the mitochondrial respiratory chain. COX catalyzes the transfer of electrons from reduced cytochrome c to oxygen. The complex contains three catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes, including COX7A2. COX7A2 encodes polypeptide 2 of subunit VIIa, present in muscle and nonmuscle tissues. Subunit VIIa also includes polypeptide 1 (muscle isoform) and a related protein found in all tissues. The COX7A2 gene may have several pseudogenes.
COX7A2 is a subunit of cytochrome c oxidase (complex IV, CIV), the final enzyme in the mitochondrial electron transport chain. This chain consists of three multisubunit complexes: succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), and cytochrome c oxidase (complex IV, CIV). Together, these complexes transfer electrons from NADH and succinate to molecular oxygen, generating an electrochemical gradient across the inner mitochondrial membrane that drives ATP synthesis. Cytochrome c oxidase specifically catalyzes the reduction of oxygen to water. It receives electrons from reduced cytochrome c in the intermembrane space, transferring them through a series of copper and heme cofactors to its active site, the binuclear center (BNC). The BNC utilizes these electrons and protons from the mitochondrial matrix to reduce oxygen to water.
COX7A2 is also known as COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL.
Associated Diseases
- microphthalmia with limb anomalies
- skin basal cell carcinoma
- COVID-19
- cancer
- osteoarthritis
- schizophrenia
- breast cancer
