COPS6
Description
The COPS6 (COP9 signalosome subunit 6) is a protein-coding gene located on chromosome 7.
COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. COPS6 has been shown to interact with EIF3S6.
COPS6, also known as SGN6, is a subunit of the COP9 signalosome complex (CSN), a key regulator in various cellular and developmental processes. The CSN complex plays a critical role in the ubiquitin (Ubl) conjugation pathway by removing NEDD8 from the cullin subunits of SCF-type E3 ligase complexes, thereby reducing their Ubl ligase activity. This includes complexes like SCF, CSA, and DDB2. Additionally, the CSN complex is involved in phosphorylation of several proteins, including p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, and IRF8, potentially through its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN respectively promotes and protects their degradation by the Ubl system. Moreover, COPS6 exhibits glucocorticoid receptor-responsive activity and stabilizes COP1 by reducing its auto-ubiquitination and slowing down its turnover rate, thus regulating the ubiquitination of COP1 targets.
COPS6 is also known as CSN6, MOV34-34KD.
