CNTRL
Description
The CNTRL (centriolin) is a protein-coding gene located on chromosome 9.
Centriolin is a protein encoded by the CNTRL gene in humans. Previously known as CEP110, it is a centrosomal protein crucial for the centrosome's function as a microtubule organizing center. It also contributes to centrosome maturation. A specific type of stem cell myeloproliferative disorder arises from a translocation between chromosomes 8 and 9, with the breakpoint affecting both fibroblast growth factor receptor 1 and centriolin.
Plays a role in cell cycle progression and cytokinesis, particularly in the final stages of cytokinesis. It anchors exocyst and SNARE complexes at the midbody, facilitating the release of secretory vesicles and the completion of cell division.
CNTRL is also known as CEP1, CEP110, FAN, bA165P4.1.
Associated Diseases
- cancer
- endometrial cancer
- thyroid gland adenocarcinoma
- ovarian cancer
- gliomatosis cerebri
- female breast carcinoma
