CNN2
Description
The CNN2 (calponin 2) is a protein-coding gene located on chromosome 19.
Calponin 2 is a protein encoded by the CNN2 gene, located at 19p13.3 in the human genome. It's one of three calponin isoforms and acts as an actin filament-associated regulatory protein with a broad tissue distribution. Human calponin 2 is a 33.7-kDa protein composed of 309 amino acids, with an isoelectric point (pI) of 7.23. It's also known as neutral calponin. Calponin isoforms are conserved proteins, but calponin 2 has diverged from the other isoforms, particularly in its C-terminal region. Evolutionarily, calponin 2 is conserved among mammals but shows more divergence in amphibians, reptiles, and fish. CNN2 is expressed in a variety of tissues and cell types, including developing and remodeling smooth muscle, adult smooth muscle, epidermal keratinocytes, fibroblasts, lung alveolar cells, endothelial cells, myeloid white blood cells, platelets, B lymphocytes, and myoblasts. These cell types are characterized by either high mechanical tension (e.g., smooth muscle), high rates of proliferation (e.g., myoblasts), or active migration (e.g., fibroblasts). Therefore, calponin 2's tissue distribution suggests a role in regulating cytoskeleton functions and cell motility.
CNN2 is also known as -.
Associated Diseases
- Alzheimer disease
- X-linked severe congenital neutropenia
- acute kidney failure
- neutropenia, severe congenital, 2, autosomal dominant
