CLIC4
Description
The CLIC4 (chloride intracellular channel 4) is a protein-coding gene located on chromosome 1.
Chloride intracellular channel 4, also known as CLIC4, p644H1, HuH1, is a eukaryotic gene. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from ischemia-reperfusion injury. They exhibit an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells). CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase, and two 14-3-3 isoforms.
CLIC4 can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. CLIC4 promotes cell-surface expression of HRH3. CLIC4 has alternate cellular functions, such as a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
CLIC4 is also known as CLIC4L, H1, MTCLIC, huH1, p64H1.
