CLEC9A
Description
The CLEC9A (C-type lectin domain containing 9A) is a protein-coding gene located on chromosome 12.
CLEC9A, short for C-type lectin domain family 9 member A, is a protein found in humans. It's encoded by the CLEC9A gene. CLEC9A is a type V C-type lectin-like receptor (CTLR) that activates cells and is found on myeloid lineage cells. This information comes from Huysamen et al. (2008) [PubMed 18408006]. The Protein Data Bank (PDB) has structural information about human CLEC9A, which can be viewed on the PDBe-KB website. This description includes text from the US National Library of Medicine, which is in the public domain.
CLEC9A functions as an endocytic receptor on a specific group of myeloid cells responsible for taking in and processing material from dead cells. It recognizes the fibrous form of actin when it's attached to certain actin-binding domains of cytoskeletal proteins like spectrin. These domains become visible when cell membranes are damaged. CLEC9A then helps present dead-cell antigens to other immune cells, a process that depends on the Syk protein. {ECO:0000269|PubMed:18497879, ECO:0000269|PubMed:22483802}
CLEC9A is also known as CD370, DNGR-1, DNGR1, UNQ9341.
