CLEC6A

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Description

The CLEC6A (C-type lectin domain containing 6A) is a protein-coding gene located on chromosome 12.

CLEC6A, also known as Dectin-2, is a protein encoded by the CLEC6A gene in humans. It belongs to the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and acts as a type II transmembrane protein with an extracellular carbohydrate recognition domain. CLEC6A functions as a pattern recognition receptor recognizing α-mannans, playing a crucial role in the innate immune response to fungi. It is expressed on macrophages and dendritic cells, and at lower levels in Langerhans cells and peripheral blood monocytes, where its expression can be induced by inflammation. The CLEC6A gene is located in the telomeric region of the natural killer gene cluster on human chromosome 12. It is part of the dectin-2 cluster, which also includes genes for DCIR, DCAR, BDCA-2, Mincle, and Clecsf8, all members of the group II C-type lectin family. CLEC6A is a glycosylated type II transmembrane protein encoded by six exons. Its structure includes a single C-type lectin (carbohydrate recognition domain, CRD) domain in its extracellular region, a stalk region, a transmembrane region, and a cytoplasmic domain.

CLEC6A acts as a pattern recognition receptor (PRR) in the innate immune system. It specifically binds to alpha-mannans, a type of sugar found on the surface of fungal pathogens like Candida albicans. This binding triggers a cascade of signaling events, leading to the activation of immune cells. These events include phosphorylation of the ITAM (immunoreceptor tyrosine-based activation motif) of FCER1G, the activation of SYK, CARD9, and NF-kappa-B, and ultimately the maturation of antigen-presenting cells. CLEC6A also plays a role in shaping the immune response to allergens from house dust mites and fungi, as well as in recognizing soluble elements from the eggs of the parasitic worm Shistosoma mansoni. These actions contribute to the overall adaptive immune response.

CLEC6A is also known as CLEC4N, CLECSF10, dectin-2, hDECTIN-2.

Associated Diseases

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