CLEC4C
Description
The CLEC4C (C-type lectin domain family 4 member C) is a protein-coding gene located on chromosome 12.
CLEC4C is a membrane protein of plasmacytoid dendritic cells used as a marker for this kind of cells and denoted as CD303 in the nomenclature of the Cluster of differentiation.
CLEC4C is a cell surface receptor that plays a role in antigen capture by dendritic cells. It specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man and binds to serum IgG. CLEC4C efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. It may mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells and act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
CLEC4C is also known as BDCA-2, BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150.
Associated Diseases
- systemic lupus erythematosus
- chronic cutaneous lupus erythematosus
- hyper-IgM syndrome type 5
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 3
- isolated agammaglobulinemia
- immunodeficiency 72 with autoinflammation
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- immunodeficiency, common variable, 4
- common variable immunodeficiency
- autoimmune lymphoproliferative syndrome type 2B
- immunodeficiency 25
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
