CLDN5
Description
The CLDN5 (claudin 5) is a protein-coding gene located on chromosome 22.
Claudin-5 is a protein encoded by the CLDN5 gene in humans. It belongs to the claudin family, which are integral membrane proteins forming tight junction strands. These strands act as a barrier, preventing the free passage of solutes and water between epithelial or endothelial cell layers. Mutations in the CLDN5 gene have been linked to velocardiofacial syndrome. Claudin-5 interacts with other claudins, specifically CLDN1 and CLDN3.
Claudin-5 plays a crucial role in forming tight junctions, which are essential for sealing the space between cells and preventing the leakage of fluids and molecules.
CLDN5 is also known as AWAL, BEC1, CPETRL1, TMDVCF, TMVCF.
