CISH
Description
The CISH (cytokine inducible SH2 containing protein) is a protein-coding gene located on chromosome 3.
CISH or cish can refer to the human gene CISH, which encodes the cytokine-inducible SH2-containing protein.
CISH plays a crucial role in regulating cytokine signaling, acting as a negative feedback mechanism. It specifically targets cytokines that utilize the JAK-STAT5 pathway, such as erythropoietin, prolactin, and interleukin 3 (IL3) receptor. CISH achieves this regulation by inhibiting the activation of STAT5, a key transcription factor, by suppressing its phosphorylation. Furthermore, CISH is suspected to be a part of a protein complex known as ECS (Elongin BC-CUL2/5-SOCS-box protein), an E3 ubiquitin-protein ligase. This complex is responsible for tagging target proteins with ubiquitin, leading to their degradation by the proteasome.
CISH is also known as BACTS2, CIS, CIS-1, G18, SOCS.
Associated Diseases
- schizophrenia
- common variable immunodeficiency
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- immunodeficiency 72 with autoinflammation
- combined immunodeficiency due to ZAP70 deficiency
- isolated agammaglobulinemia
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- severe combined immunodeficiency due to CARD11 deficiency
