CIDEA

Description

The CIDEA (cell death inducing DFFA like effector a) is a protein-coding gene located on chromosome 18.

CIDEA is a protein encoded by the CIDEA gene in humans. It plays a crucial role in regulating the secretion of milk lipids in the mammary gland and is a homolog of the mouse Cidea protein, which has been implicated in apoptosis. While CIDEA's activation of apoptosis is inhibited by DFF45, it's not affected by caspase inhibitors. Mice lacking functional Cidea exhibit higher metabolic rates, increased lipolysis in brown adipose tissue, and higher body temperatures when exposed to cold. These mice are also resistant to obesity and diabetes induced by diet, suggesting CIDEA's involvement in thermogenesis and lipolysis. Two different isoforms of CIDEA are produced from alternative transcripts.

CIDEA promotes the formation of large, single lipid droplets by mediating their fusion. This fusion process restricts the breakdown of fats (lipolysis) and favors their storage. CIDEA localizes to the surface of lipid droplets and facilitates the transfer of neutral lipids from smaller to larger droplets. This transfer is driven by the pressure difference between the droplets and occurs at a slower rate than that promoted by CIDEC. CIDEA can also act as a coactivator of CEBPB, a transcription factor, in epithelial cells. This coactivation regulates the expression of several genes involved in cell growth and metabolism, including ID2, IGF1, PRLR, SOCS1, SOCS3, and XDH. CIDEA interacts with CEBPB to enhance its binding to the XDH promoter, leading to increased histone acetylation and removal of HDAC1 from the promoter. Overexpression of CIDEA has been linked to apoptosis (programmed cell death), but the physiological significance of this role remains unclear.

CIDEA is also known as CIDE-A.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing