CHD1L

Description

The CHD1L (chromodomain helicase DNA binding protein 1 like) is a protein-coding gene located on chromosome 1.

CHD1L (ALC1) is an enzyme that in humans is encoded by the CHD1L gene. It is involved in chromatin remodeling and DNA relaxation, processes crucial for DNA replication, repair, and transcription. CHD1L contains an ATPase domain and a macro domain. Due to similarities in the ATPase domain, CHD1L belongs to the Snf2 family. It consists of 897 amino acids and has an approximate size of 101 kDa. In development, CHD1L, a DNA helicase, exhibits chromatin remodeling activity and interacts with PARP1/PARylation in regulating pluripotency during developmental reprogramming. The macro-domain of CHD1L interacts with the PAR moiety of PARylated-PARP1 to facilitate early-stage reprogramming and pluripotency in stem cells. CHD1L expression appears crucial for early events in embryonic development. During DNA repair, the chromatin must undergo remodeling at sites of damage to allow the critical cellular process to occur. CHD1L, a chromatin remodeling protein, plays a crucial role in this early stage of DNA repair.

CHD1L is an ATP-dependent chromatin remodeler that plays a critical role in DNA repair by mediating chromatin remodeling following DNA damage. It is recruited to DNA damage sites through interaction with poly-ADP-ribose, specifically recognizing and binding histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. This interaction activates CHD1L's ATP-dependent chromatin remodeler activity, allowing it to regulate chromatin during DNA repair. CHD1L catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner, which helps to create space for repair machinery to access the damaged DNA. Moreover, CHD1L's chromatin remodeling activity promotes the removal of PARP2 from chromatin, further contributing to the DNA repair process.

CHD1L is also known as ALC1, CHDL.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing